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So far SMI has created 144 entries.

Harvesting Alveolar Macrophages from the Mouse

Harvesting Alveolar Macrophages from the Mouse Using Lung Lavage

Chavez-Santoscoy AV, Huntimer LM, Ramer-Tait AE, Wannemuehler M, Narasimhan B: Harvesting murine alveolar macrophages and evaluating cellular activation induced by polyanhydride nanoparticles. Journal of visualized experiments : JoVE 2012(64):e3883.

Biodegradable nanoparticles have emerged as a versatile platform for the design and implementation of new intranasal vaccines against […]

By |March 15th, 2017|Categories: Protocols, Publications, Respiratory System||0 Comments

Murine Model of DSS-induced Acute Colitis

Murine Model of DSS-induced Acute Colitis

J Vis Exp. 2012 Feb 1;(60). pii: 3678. doi: 10.3791/3678. Investigating intestinal inflammation in DSS-induced model of IBD. Kim JJ1, Shajib MS, Manocha MM, Khan WI. 

Inflammatory bowel disease (IBD) encompasses a range of intestinal pathologies, the most common of which are ulcerative colitis (UC) and Crohn’s Disease (CD). Both UC […]

By |February 27th, 2017|Categories: Gastrointestinal System, Protocols, Publications||0 Comments

Airway Hyperresponsiveness in Murine Tracheal Rings

Assessment of Airway Hyperresponsiveness in Murine Tracheal Rings. Methods Mol Biol. 2013;1032:257-69. doi: 10.1007/978-1-62703-496-8_20.

Isolated tracheal rings have often been used to directly measure the contractile output of airway smooth muscle (ASM). Here, we describe the method for excising murine tracheas, mounting tracheal rings in organ baths, and measuring the isometric forces generated by the ASM when […]

By |February 12th, 2017|Categories: Protocols, Respiratory System||0 Comments

Vertically Transmitted Fecal IgA Levels Determine Phenotypic Variation

Vertically Transmitted Fecal IgA Levels Determine Extra-Chromosomal Phenotypic Variation

Moon C, Baldridge MT, Wallace MA, Burnham CA, Virgin HW, Stappenbeck TS.

Nature. 2015 Feb 16. doi: 10.1038/nature14139. [Epub ahead of print]

Phenotypic variation between apparently genetically identical mice at different facilities/institutions has been a challenge facing investigators working in many different murine experimental systems. Differences in commensal […]

By |May 1st, 2015|Categories: 2015, 2015 Featured Papers, April 2015, News||0 Comments

Grand Challenges Explorations (GCE) Applications

Grand Challenges Explorations (GCE) has opened application Round 15, and proposals for the six topics listed below are being accepted online through May 13, 2015.

GCE Round 15 topics:
• Addressing Newborn and Infant Gut Health Through Bacteriophage-Mediated Microbiome Engineering
• Explore New Ways to Measure Delivery and Use of Digital Financial Services Data
• Surveillance […]

By |March 23rd, 2015|Categories: 2015, News||0 Comments

Commensal Gram-positive Bacteria Initiate Colitis

Commensal Gram-positive Bacteria Initiates Colitis by Inducing Monocyte/Macrophage Mobilization

Y Nakanishi, T Sato and T Ohteki.

Mucosal Immunology (2015) 8, 152–160; doi:10.1038/mi.2014.53; published online 18 June 2014

The commensal bacteria in the intestine benefit the host immune response. However, breakdown of the intestinal epithelial layer’s barrier function results in the inflow of commensal flora and improper immune […]

Species-specific Expression of Colon T Cell Homing

Role and Species-specific Expression of Colon T Cell Homing Receptor GPR15 in Colitis

Nguyen LP, Pan J, Dinh TT, Hadeiba H, O’Hara E 3rd, Ebtikar A, Hertweck A, Gökmen MR, Lord GM, Jenner RG, Butcher EC, Habtezion A.

Nat Immunol. 2015 Feb;16(2):207-13. doi: 10.1038/ni.3079. Epub 2014 Dec 22.

Recruitment of lymphocytes from circulation is a tissue- and […]

Interleukin (IL)-21 Promotes Intestinal IgA Responses to Microbiota

Interleukin (IL)-21 Promotes Intestinal IgA Responses to Microbiota

Cao AT, Yao S, Gong B, Nurieva RI, Elson CO, Cong Y.

Mucosal Immunol. 2015 Jan 14. doi: 10.1038/mi.2014.134.

The intestinal tract is colonized by trillions of commensal bacteria that live in a mutualistic relationship our bodies. Commensal microbiota-specific Th17 cells are enriched in the intestines and are crucial […]

MyD88 Signaling in T Cells Directs IgA-Mediate Control of Microbiota

MyD88 Signaling in T Cells Directs IgA-Mediated Control of the Microbiota to Promote Health

Jason L. Kubinak, Charisse Petersen, W. Zac Stephens, Ray Soto, Erin Bake, Ryan M. O’Connell, June L. Round.

http://dx.doi.org/10.1016/j.chom.2014.12.009

Alterations to the commensal communities on our bodies can lead to disease, however the mechanisms by which the host can control and sculpt the […]

Lori Rathje Named Executive Director of SMI

Lori Rathje, CAE, has been named Executive Director of the Society for Mucosal Immunology. Lori was previously Association Manager for SMI and served in that position since 2008.

“I am honored to serve as Executive Director of SMI, and to have the opportunity to work with such distinguished leaders to advance their mission,” Rathje said.

Lori […]

By |February 4th, 2015|Categories: 2015, News||0 Comments