Effects of a gut pathobiont in a gnotobiotic mouse model of childhood undernutrition

By Vitas E. Wagner, Neelendu Dey, Janaki Guruge, Ansel Hsiao, Philip P. Ahern, Nicholas P. Semenkovich, Laura V. Blanton, Jiye Cheng, Nicholas Griffin, Thaddeus S. Stappenbeck, Olga Ilkayeva, Christopher B. Newgard, William Petri, Rashidul Haque, Tahmeed Ahmed and Jeffrey I. Gordon

Childhood undernutrition is a pressing global health challenge.

Children with moderate or severe undernutrition exhibit […]

Interactions between the microbiota and pathogenic bacteria in the gut

By Andreas Baumler & Vanessa Sperandio

The microbiome plays an important role in human health.

Recent studies highlight that microbiota changes can confer resistance or promote infection by bacterial pathogens. Antibiotics have profound impacts on the microbial community, therefore altering the nutritional landscape in the gut, which can lead to pathogen expansion. Pathogens exploit microbiota-derived carbon […]

Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species

By Guilliams M, Dutertre CA, Scott CL, McGovern N, Sichien D, Chakarov S, Van Gassen S, Chen J, Poidinger M, De Prijck S, Tavernier SJ, Low I, Irac SE, Mattar CN, Sumatoh HR, Low G, Chung J, Chan D, Tan KK, Tony Lim KH, Fossum E, Bogen B, Choolani M, Chan J, Larbi A, […]

Secretory leukoprotease inhibitor is required for efficient quercetin-mediated suppression of TNFα secretion

Stefania De Santis, Dale Kunde, Grazia Serino, Vanessa Galleggiante, Maria Lucia Caruso, Mauro Mastronardi, Elisabetta Cavalcanti, Nicole Ranson, Aldo Pinto, Pietro Campiglia, Angelo Santino, Rajaraman Eri, Marcello Chieppa

Our data encourages the development of nutritional strategies to improve the efficiency of current therapies for intestinal chronic inflammatory syndrome and reduce the risks of colorectal cancer […]

Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments

Rafael Di Marco Barros, Natalie A. Roberts, Robin J. Dart, Pierre Vantourout, Anett Jandke,
Oliver Nussbaumer, Livija Deban, Sara Cipolat, Rosie Hart, Maria Luisa Iannitto, Adam Laing,
Bradley Spencer-Dene, Philip East, Deena Gibbons, Peter M. Irving, Pablo Pereira, Ulrich Steinhoff,
and Adrian Hayday

A conserved biology emerges linking mucosal and skin intraepithelial lymphocyte (IEL) biology and mucosal IEL […]