Effects of a gut pathobiont in a gnotobiotic mouse model of childhood undernutrition

By Vitas E. Wagner, Neelendu Dey, Janaki Guruge, Ansel Hsiao, Philip P. Ahern, Nicholas P. Semenkovich, Laura V. Blanton, Jiye Cheng, Nicholas Griffin, Thaddeus S. Stappenbeck, Olga Ilkayeva, Christopher B. Newgard, William Petri, Rashidul Haque, Tahmeed Ahmed and Jeffrey I. Gordon

Childhood undernutrition is a pressing global health challenge.

Children with moderate or severe undernutrition exhibit […]

Interactions between the microbiota and pathogenic bacteria in the gut

By Andreas Baumler & Vanessa Sperandio

The microbiome plays an important role in human health.

Recent studies highlight that microbiota changes can confer resistance or promote infection by bacterial pathogens. Antibiotics have profound impacts on the microbial community, therefore altering the nutritional landscape in the gut, which can lead to pathogen expansion. Pathogens exploit microbiota-derived carbon […]

Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species

By Guilliams M, Dutertre CA, Scott CL, McGovern N, Sichien D, Chakarov S, Van Gassen S, Chen J, Poidinger M, De Prijck S, Tavernier SJ, Low I, Irac SE, Mattar CN, Sumatoh HR, Low G, Chung J, Chan D, Tan KK, Tony Lim KH, Fossum E, Bogen B, Choolani M, Chan J, Larbi A, […]

Secretory leukoprotease inhibitor is required for efficient quercetin-mediated suppression of TNFα secretion

Stefania De Santis, Dale Kunde, Grazia Serino, Vanessa Galleggiante, Maria Lucia Caruso, Mauro Mastronardi, Elisabetta Cavalcanti, Nicole Ranson, Aldo Pinto, Pietro Campiglia, Angelo Santino, Rajaraman Eri, Marcello Chieppa

Our data encourages the development of nutritional strategies to improve the efficiency of current therapies for intestinal chronic inflammatory syndrome and reduce the risks of colorectal cancer […]

Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments

Rafael Di Marco Barros, Natalie A. Roberts, Robin J. Dart, Pierre Vantourout, Anett Jandke,
Oliver Nussbaumer, Livija Deban, Sara Cipolat, Rosie Hart, Maria Luisa Iannitto, Adam Laing,
Bradley Spencer-Dene, Philip East, Deena Gibbons, Peter M. Irving, Pablo Pereira, Ulrich Steinhoff,
and Adrian Hayday

A conserved biology emerges linking mucosal and skin intraepithelial lymphocyte (IEL) biology and mucosal IEL […]

IL-33 regulates the IgA-microbiota axis to restrain IL-1α–dependent colitis and tumorigenesis

Ankit Malik, Deepika Sharma, Qifan Zhu, Rajendra Karki, Clifford S. Guy, Peter Vogel, and Thirumala-Devi Kanneganti

Inflammatory bowel diseases (IBD) affect over 5 million individuals in the industrialized world, with an increasing incidence rate worldwide. IBD also predisposes affected individuals to development of colorectal cancer, which is a leading cause of cancer-related deaths in adults. […]

Lymphoid Aggregates Remodel Lymphatic Collecting Vessels that Serve Mesenteric Lymph Notes in Crohn Disease

Gwendalyn J. Randolph, Shashi Bala, Jean-François Rahier, Michael W. Johnson, Peter L. Wang, ILKe Nalbantoglu, Laurent Dubuquoy, Amélie Chau, Benjamin Pariente, Alex Kartheuser, Bernd H. Zinselmeyer, and Jean-Frederic Colombel

Early pathological descriptions of Crohn disease (CD) argued for a potential defect in lymph transport; however, this concept has not been thoroughly investigated. In mice, poor […]

By |November 23rd, 2016|Categories: Featured Papers, November 2016||0 Comments

Control of Paneth Cell Fate by PKCλ/ι

Control of Paneth Cell Fate, Intestinal Inflammation, and Tumorigenesis by PKCλ/ι
Yuki Nakanishi, Miguel Reina-Campos, Naoko Nakanishi, Victoria Llado, Lisa Elmen, Scott Peterson, Alex Campos, Surya K. De, Michael Leitges, Hiroki Ikeuchi, Maurizio Pellecchia, Richard S. Blumberg, Maria T. Diaz-Meco, and Jorge Moscat

The intestine is protected by specialized cells, called Paneth cells, that secrete antimicrobial […]

Maternal IgG and IgA Antibodies Dampen Mucosal T Helper Cell

Maternal IgG and IgA Antibodies Dampen Mucosal T Helper Cell Responses in Early Life
Koch MA, Reiner GL, Lugo KA, Kreuk LS, Stanbery AG, Ansaldo E, Seher TD, Ludington WB, Barton GM.

Immediately following birth, the gastrointestinal tract is colonized by diverse microbial species. Establishing proper immune responses to these microbes is essential to ensure optimal […]

IgA Production Requires B Cell Interaction with Subepithelial

IgA Production Requires B Cell Interaction with Subepithelial Dendritic Cells in Peyer’s Patches
Reboldi A, Arnon TI, Rodda LB, Atakilit A, Sheppard D, Cyster JG.

Immunoglobulin A (IgA) induction primarily occurs in intestinal Peyer’s patches (PPs). However, the cellular interactions necessary for IgA class switching are poorly defined. Here we show that in mice, activated B […]