Endoscopic Photoconversion Reveals Trafficking to the Gut

Endoscopic Photoconversion Reveals Unexpectedly Broad Leukocyte Trafficking to and from the Gut

Morton AM, Sefik E, Upadhyay R, Weissleder R, Benoist C, Mathis D.

Proc Natl Acad Sci U S A. 2014 May 6;111(18):6696-701. doi: 10.1073/pnas.1405634111. Epub 2014 Apr 21.

Gut-microbiota/immune-cell interactions play important roles in immune system homeostasis and responsiveness, and have been implicated in the […]

Constant Replenishment from Circulating Monocytes in Adult Mice

Constant Replenishment from Circulating Monocytes Maintains the Macrophage Pool in the Intestine of Adult Mice

Bain CC, Bravo-Blas A, Scott CL, Gomez Perdiguero E, Geissmann F, Henri S, Malissen B, Osborne LC, Artis D, Mowat AM.

Nat Immunol. 2014 Aug 24. doi: 10.1038/ni.2967.

The normal intestine contains large numbers of macrophages that play crucial roles in homeostasis, […]

Transcription Factor T Bet Regulates Lymphocyte Maturation

Transcription Factor T-bet Regulates Intraepithelial Lymphocyte Functional Maturation

Reis BS, Hoytema van Konijnenburg DP, Grivennikov SI, Mucida D.

Immunity. 2014 Aug 21;41(2):244-56. doi: 10.1016/j.immuni.2014.06.017.

IELs police the single-cell layer of intestinal epithelium, a fine boundary that spans as much as 400 square meters and allows nutrients in and wastes out. Nearly all IELs belong to a group […]

Transcription Factor T Bet is Induced by IL-15

The Transcription Factor T Bet Is Induced by IL-15 and Thymic Agonist Selection and Controls CD8αα(+) Intraepithelial Lymphocyte Development

Klose CS, Blatz K, d’Hargues Y, Hernandez PP, Kofoed-Nielsen M, Ripka JF, Ebert K, Arnold SJ, Diefenbach A, Palmer E, Tanriver Y.

Immunity. 2014 Aug 21;41(2):230-43. doi: 10.1016/j.immuni.2014.06.018.

CD8αα(+) intraepithelial lymphocytes (IELs) are instrumental in maintaining the epithelial […]