2015 Featured Papers

Epithelial-Derived IL-18 Regulates Th17 Cell Differentiation

Epithelial-Derived IL-18 Regulates Th17 Cell Differentiation and Foxp3(+) Treg Cell Function in the Intestine

Harrison OJ, Srinivasan N, Pott J, Schiering C, Krausgruber T, Ilott NE, Maloy

Intestinal immune homeostasis is maintained through a constant molecular dialogue between commensal microbiota, intestinal tissue cells, and the mucosal immune system. Breakdown of this mutualistic relationship results in chronic pathologies […]

Mongersen, an Oral SMAD7 Antisense Oligonucleotide

Mongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohn’s Disease

 

 
Giovanni Monteleone, M.D., Ph.D., Markus F. Neurath, M.D., Ph.D., Sandro Ardizzone, M.D., Antonio Di Sabatino, M.D., Massimo C. Fantini, M.D., Ph.D., Fabiana Castiglione, M.D., Maria L. Scribano, M.D., Alessandro Armuzzi, M.D., Ph.D., Flavio Caprioli, M.D., Ph.D., Giacomo C. Sturniolo, M.D., Francesca Rogai, M.D., Ph.D., Maurizio Vecchi, […]

An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid

An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses

Teruyuki Sano, Wend Huang, Jason A. Hall, Yi Yang, Alessandra Chen, Samuel J. Gavzy, June-Yong Lee, Joshua W. Ziel, Emily R. Miraldi, Ana I. Damingos, Richard Bonneau and Dan R. Littman.

RORγt+ Th17 cells are important for mucosal defenses, but also contribute […]

Early Infancy Microbial and Metabolic Alterations Affect Risk of

Early Infancy Microbial and Metabolic Alterations Affect Risk of Childhood Asthma

Marie-Claire Arrieta, Leah T. Stiemsma, Pedro A. Dimitriu, Lisa Thorson, Shannon Russell,Sophie Yurist-Doutsch, Boris Kuzeljevic, Matthew J. Gold, Heidi M. Britton, Diana L. Lefebvre,Padmaja Subbarao, Piush Mandhane, Allan Becker, Kelly M. McNagny, Malcolm R. Sears, Tobias Kollmann, the CHILD Study Investigators, William W. Mohn, Stuart E. Turvey and B. Brett Finlay

Asthma currently affects over 300 million people worldwide and is the most […]

Functional Characterization of IgA-Targeted Bacterial Taxa

Functional Characterization of IgA-Targeted Bacterial Taxa from Undernourished Malawian Children that Produce Diet-Dependent Enteropathy

Andrew L. Kau, Joseph D. Planer, Jie Liu, Sindhuja Rao, Tanya Yatsunenko, Indi Trehan, Mark J. Manary, Ta-Chiang Liu, Thaddeus S. Stappenbeck, Kenneth M. Maleta, Per Ashorn, Kathryn G. Dewey, Eric R. Houpt, Chyi-Song Hsieh and Jeffrey I. Gordon

Understanding how the […]

Vitamin B12 Modulates the Transcriptome of the Skin

Vitamin B12 Modulates the Transcriptome of the Skin Microbiota in Acne Pathogenesis

Dezhi Kang, Baochen Shi, Marie C. Erfe, Noah Craft and Huiying Li.

Skin bacteria are thought to play an important role in the development of acne vulgaris, one of the most common skin diseases throughout the world. However, the bacterial pathogenesis mechanism has not […]

A Mucosal Vaccine Against Chlamydia Trachomatis

A Mucosal Vaccine Against Chlamydia Trachomatis Generates Two Waves of Protective Memory T cells

Georg Stary, Andrew Olive, Aleksandar F. Radovic-Moreno, David Gondek, David Alvarez, Pamela A. Basto, Mario Perro, Vladimir D. Vrbanac, Andrew M. Tager, Jinjun Shi, Jeremy A. Yethon, Omid C. Farokhzad, Robert Langer, Michael N. Starnbach, Ulrich H. von Andrian

Science. 2015 Jun 19;348(6241):aaa8205. doi: 10.1126/science.aaa8205.

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Interferon-λ and Interleukin 22 Act Synergistically

Interferon-λ and Interleukin 22 Act Synergistically for the Induction of Interferon-Stimulated Genes and Control of Rotavirus Infection

Pedro P Hernández, Tanel Mahlakõiv, Ines Yang, Vera Schwierzeck, Nam Nguye,
Fabian Guendel, Konrad Gronke, Bernhard Ryffel, Christoph Hölscher, Laure Dumoutier, Jean-Christophe Renauld, Sebastian Suerbaum, Peter Staeheli & Andreas Diefenbach

Nat Immunol. 2015 Jul;16(7):698-707. doi: 10.1038/ni.3180. Epub 2015 May 25.

 

 

 

 

 

Emerging […]

Vertically Transmitted Fecal IgA Levels Determine Phenotypic Variation

Vertically Transmitted Fecal IgA Levels Determine Extra-Chromosomal Phenotypic Variation

Moon C, Baldridge MT, Wallace MA, Burnham CA, Virgin HW, Stappenbeck TS.

Nature. 2015 Feb 16. doi: 10.1038/nature14139. [Epub ahead of print]

Phenotypic variation between apparently genetically identical mice at different facilities/institutions has been a challenge facing investigators working in many different murine experimental systems. Differences in commensal […]

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Commensal Gram-positive Bacteria Initiate Colitis

Commensal Gram-positive Bacteria Initiates Colitis by Inducing Monocyte/Macrophage Mobilization

Y Nakanishi, T Sato and T Ohteki.

Mucosal Immunology (2015) 8, 152–160; doi:10.1038/mi.2014.53; published online 18 June 2014

The commensal bacteria in the intestine benefit the host immune response. However, breakdown of the intestinal epithelial layer’s barrier function results in the inflow of commensal flora and improper immune […]