February 2015

Commensal Gram-positive Bacteria Initiate Colitis

Commensal Gram-positive Bacteria Initiates Colitis by Inducing Monocyte/Macrophage Mobilization

Y Nakanishi, T Sato and T Ohteki.

Mucosal Immunology (2015) 8, 152–160; doi:10.1038/mi.2014.53; published online 18 June 2014

The commensal bacteria in the intestine benefit the host immune response. However, breakdown of the intestinal epithelial layer’s barrier function results in the inflow of commensal flora and improper immune […]

Species-specific Expression of Colon T Cell Homing

Role and Species-specific Expression of Colon T Cell Homing Receptor GPR15 in Colitis

Nguyen LP, Pan J, Dinh TT, Hadeiba H, O’Hara E 3rd, Ebtikar A, Hertweck A, Gökmen MR, Lord GM, Jenner RG, Butcher EC, Habtezion A.

Nat Immunol. 2015 Feb;16(2):207-13. doi: 10.1038/ni.3079. Epub 2014 Dec 22.

Recruitment of lymphocytes from circulation is a tissue- and […]

Interleukin (IL)-21 Promotes Intestinal IgA Responses to Microbiota

Interleukin (IL)-21 Promotes Intestinal IgA Responses to Microbiota

Cao AT, Yao S, Gong B, Nurieva RI, Elson CO, Cong Y.

Mucosal Immunol. 2015 Jan 14. doi: 10.1038/mi.2014.134.

The intestinal tract is colonized by trillions of commensal bacteria that live in a mutualistic relationship our bodies. Commensal microbiota-specific Th17 cells are enriched in the intestines and are crucial […]

MyD88 Signaling in T Cells Directs IgA-Mediate Control of Microbiota

MyD88 Signaling in T Cells Directs IgA-Mediated Control of the Microbiota to Promote Health

Jason L. Kubinak, Charisse Petersen, W. Zac Stephens, Ray Soto, Erin Bake, Ryan M. O’Connell, June L. Round.

http://dx.doi.org/10.1016/j.chom.2014.12.009

Alterations to the commensal communities on our bodies can lead to disease, however the mechanisms by which the host can control and sculpt the […]