Control of Paneth Cell Fate by PKCλ/ι

Control of Paneth Cell Fate, Intestinal Inflammation, and Tumorigenesis by PKCλ/ι
Yuki Nakanishi, Miguel Reina-Campos, Naoko Nakanishi, Victoria Llado, Lisa Elmen, Scott Peterson, Alex Campos, Surya K. De, Michael Leitges, Hiroki Ikeuchi, Maurizio Pellecchia, Richard S. Blumberg, Maria T. Diaz-Meco, and Jorge Moscat

The intestine is protected by specialized cells, called Paneth cells, that secrete antimicrobial […]

Maternal IgG and IgA Antibodies Dampen Mucosal T Helper Cell

Maternal IgG and IgA Antibodies Dampen Mucosal T Helper Cell Responses in Early Life
Koch MA, Reiner GL, Lugo KA, Kreuk LS, Stanbery AG, Ansaldo E, Seher TD, Ludington WB, Barton GM.

Immediately following birth, the gastrointestinal tract is colonized by diverse microbial species. Establishing proper immune responses to these microbes is essential to ensure optimal […]

IgA Production Requires B Cell Interaction with Subepithelial

IgA Production Requires B Cell Interaction with Subepithelial Dendritic Cells in Peyer’s Patches
Reboldi A, Arnon TI, Rodda LB, Atakilit A, Sheppard D, Cyster JG.

Immunoglobulin A (IgA) induction primarily occurs in intestinal Peyer’s patches (PPs). However, the cellular interactions necessary for IgA class switching are poorly defined. Here we show that in mice, activated B […]

Group 2 Innate Lymphoid Cells Utilize the IRF4-IL-9

Group 2 Innate Lymphoid Cells Utilize the IRF4-IL-9 Module to Coordinate Epithelial Cell Maintenance of Lung Homeostasis
Mohapatra A, Van Dyken SJ, Schneider C, Nussbaum JC, Liang HE, Locksley RM

Group 2 innate lymphoid cells (ILC2s) in lung are among the initial cells that respond to allergen-provoking challenges, but how signals are integrated to mediate their […]

Dietary Antigens Limit Mucosal Immunity by Inducing

Dietary Antigens Limit Mucosal Immunity by Inducing Regulatory T Cells in the Small Intestine
Kwang Soon Kim, Sung-Wook Hong, Daehee Han, Jaeu Yi, Jisun Jung, Bo-Gie Yang, Jun Young Lee, Minji Lee, Charles D. Surh

The gastrointestinal organs are chronically exposed to massive amount of diverse enteric antigens (Ags), most derived from diet and intestinal microbes both of which are benign and beneficial to […]

Anticancer Immunotherapy by CTLA-4 Blockade Relies on

Anticancer Immunotherapy by CTLA-4 Blockade Relies on the Gut Microbiota

Marie Vétizou, Jonathan M. Pitt, Romain Daillère, Patricia Lepage, Nadine Waldschmitt, Caroline Flament, Sylvie Rusakiewicz, Bertrand Routy, Maria P. Roberti, Connie P. M. Duong, Vichnou Poirier-Colame, Antoine Roux, Sonia Becharef, Silvia Formenti, Encouse Golden, Sascha Cording, Gerard Eber, Andreas Schlitzer, Florent Ginhoux, Sridhar Mani, Takahiro […]