Featured Papers

Group 2 Innate Lymphoid Cells Utilize the IRF4-IL-9

Group 2 Innate Lymphoid Cells Utilize the IRF4-IL-9 Module to Coordinate Epithelial Cell Maintenance of Lung Homeostasis
Mohapatra A, Van Dyken SJ, Schneider C, Nussbaum JC, Liang HE, Locksley RM

Group 2 innate lymphoid cells (ILC2s) in lung are among the initial cells that respond to allergen-provoking challenges, but how signals are integrated to mediate their […]

Dietary Antigens Limit Mucosal Immunity by Inducing

Dietary Antigens Limit Mucosal Immunity by Inducing Regulatory T Cells in the Small Intestine
Kwang Soon Kim, Sung-Wook Hong, Daehee Han, Jaeu Yi, Jisun Jung, Bo-Gie Yang, Jun Young Lee, Minji Lee, Charles D. Surh

The gastrointestinal organs are chronically exposed to massive amount of diverse enteric antigens (Ags), most derived from diet and intestinal microbes both of which are benign and beneficial to […]

Anticancer Immunotherapy by CTLA-4 Blockade Relies on

Anticancer Immunotherapy by CTLA-4 Blockade Relies on the Gut Microbiota

Marie Vétizou, Jonathan M. Pitt, Romain Daillère, Patricia Lepage, Nadine Waldschmitt, Caroline Flament, Sylvie Rusakiewicz, Bertrand Routy, Maria P. Roberti, Connie P. M. Duong, Vichnou Poirier-Colame, Antoine Roux, Sonia Becharef, Silvia Formenti, Encouse Golden, Sascha Cording, Gerard Eber, Andreas Schlitzer, Florent Ginhoux, Sridhar Mani, Takahiro […]

Epithelial-Derived IL-18 Regulates Th17 Cell Differentiation

Epithelial-Derived IL-18 Regulates Th17 Cell Differentiation and Foxp3(+) Treg Cell Function in the Intestine

Harrison OJ, Srinivasan N, Pott J, Schiering C, Krausgruber T, Ilott NE, Maloy

Intestinal immune homeostasis is maintained through a constant molecular dialogue between commensal microbiota, intestinal tissue cells, and the mucosal immune system. Breakdown of this mutualistic relationship results in chronic pathologies […]

Mongersen, an Oral SMAD7 Antisense Oligonucleotide

Mongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohn’s Disease

 

 
Giovanni Monteleone, M.D., Ph.D., Markus F. Neurath, M.D., Ph.D., Sandro Ardizzone, M.D., Antonio Di Sabatino, M.D., Massimo C. Fantini, M.D., Ph.D., Fabiana Castiglione, M.D., Maria L. Scribano, M.D., Alessandro Armuzzi, M.D., Ph.D., Flavio Caprioli, M.D., Ph.D., Giacomo C. Sturniolo, M.D., Francesca Rogai, M.D., Ph.D., Maurizio Vecchi, […]

An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid

An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses

Teruyuki Sano, Wend Huang, Jason A. Hall, Yi Yang, Alessandra Chen, Samuel J. Gavzy, June-Yong Lee, Joshua W. Ziel, Emily R. Miraldi, Ana I. Damingos, Richard Bonneau and Dan R. Littman.

RORγt+ Th17 cells are important for mucosal defenses, but also contribute […]

Early Infancy Microbial and Metabolic Alterations Affect Risk of

Early Infancy Microbial and Metabolic Alterations Affect Risk of Childhood Asthma

Marie-Claire Arrieta, Leah T. Stiemsma, Pedro A. Dimitriu, Lisa Thorson, Shannon Russell,Sophie Yurist-Doutsch, Boris Kuzeljevic, Matthew J. Gold, Heidi M. Britton, Diana L. Lefebvre,Padmaja Subbarao, Piush Mandhane, Allan Becker, Kelly M. McNagny, Malcolm R. Sears, Tobias Kollmann, the CHILD Study Investigators, William W. Mohn, Stuart E. Turvey and B. Brett Finlay

Asthma currently affects over 300 million people worldwide and is the most […]

Functional Characterization of IgA-Targeted Bacterial Taxa

Functional Characterization of IgA-Targeted Bacterial Taxa from Undernourished Malawian Children that Produce Diet-Dependent Enteropathy

Andrew L. Kau, Joseph D. Planer, Jie Liu, Sindhuja Rao, Tanya Yatsunenko, Indi Trehan, Mark J. Manary, Ta-Chiang Liu, Thaddeus S. Stappenbeck, Kenneth M. Maleta, Per Ashorn, Kathryn G. Dewey, Eric R. Houpt, Chyi-Song Hsieh and Jeffrey I. Gordon

Understanding how the […]

Vitamin B12 Modulates the Transcriptome of the Skin

Vitamin B12 Modulates the Transcriptome of the Skin Microbiota in Acne Pathogenesis

Dezhi Kang, Baochen Shi, Marie C. Erfe, Noah Craft and Huiying Li.

Skin bacteria are thought to play an important role in the development of acne vulgaris, one of the most common skin diseases throughout the world. However, the bacterial pathogenesis mechanism has not […]

A Mucosal Vaccine Against Chlamydia Trachomatis

A Mucosal Vaccine Against Chlamydia Trachomatis Generates Two Waves of Protective Memory T cells

Georg Stary, Andrew Olive, Aleksandar F. Radovic-Moreno, David Gondek, David Alvarez, Pamela A. Basto, Mario Perro, Vladimir D. Vrbanac, Andrew M. Tager, Jinjun Shi, Jeremy A. Yethon, Omid C. Farokhzad, Robert Langer, Michael N. Starnbach, Ulrich H. von Andrian

Science. 2015 Jun 19;348(6241):aaa8205. doi: 10.1126/science.aaa8205.

[…]