Innate-type Lymphocytes in the Intestinal Epithelium

CD8αα+ Innate-type Lymphocytes in the Intestinal Epithelium Mediate Mucosal Immunity

Van Kaer L, Algood HM, Singh K, Parekh VV, Greer MJ, Piazuelo MB, Weitkamp JH, Matta P, Chaturvedi R, Wilson KT, Olivares-Villagómez D.

Immunity. 2014 Sep 18;41(3):451-64. doi: 10.1016/j.immuni.2014.08.010. Epub 2014 Sep 11.

Innate immune responses are critical for mucosal immunity. In this publication we describe an […]

Precision Microbiome Restores Bile Acid Resistance to Clostridium Difficile

Precision Microbiome Reconstitution Restores Bile Acid Mediated Resistance to Clostridium Difficile

Buffie CG, Bucci V, Stein RR, McKenney PT, Ling L, Gobourne A, No D, Liu H, Kinnebrew M, Viale A, Littmann E, van den Brink MR, Jenq RR, Taur Y, Sander C, Cross J, Toussaint NC, Xavier JB, Pamer EG.

Nature. 2014 Oct 22. doi: […]

Local Macrophage Chemokine Sustain Protective CD4 T Cells

A Local Macrophage Chemokine Network Sustains Protective Tissue-resident Member CD4 T Cells

Science. 2014 Oct 3;346(6205):93-8. doi: 10.1126/science.1257530. Epub 2014 Aug 28.

Despite large investment and effort, vaccines that rely on T cells have not been successful. Unlike antibody-based vaccines, T cell-based vaccines rely on the cellular recruitment to the site of infection for protection. However, […]

By |October 13th, 2014|Categories: 2014 Featured Papers, October 2014||0 Comments

Commensal Bacteria Protect against Food Allergen Sensitization

Commensal Bacteria Protect against Food Allergen Sensitization

Stefka, AT et al  Commensal bacteria protect against food allergen sensitization.  2014 PNAS USA 111, 13145-13150.

The prevalence of life-threatening anaphylactic responses to food is rising at an alarming rate in many parts of the world. It is increasingly clear that 21st century environmental interventions, including widespread antibiotic use, […]

By |October 10th, 2014|Categories: 2014 Featured Papers, October 2014||0 Comments

Endoscopic Photoconversion Reveals Trafficking to the Gut

Endoscopic Photoconversion Reveals Unexpectedly Broad Leukocyte Trafficking to and from the Gut

Morton AM, Sefik E, Upadhyay R, Weissleder R, Benoist C, Mathis D.

Proc Natl Acad Sci U S A. 2014 May 6;111(18):6696-701. doi: 10.1073/pnas.1405634111. Epub 2014 Apr 21.

Gut-microbiota/immune-cell interactions play important roles in immune system homeostasis and responsiveness, and have been implicated in the […]

Constant Replenishment from Circulating Monocytes in Adult Mice

Constant Replenishment from Circulating Monocytes Maintains the Macrophage Pool in the Intestine of Adult Mice

Bain CC, Bravo-Blas A, Scott CL, Gomez Perdiguero E, Geissmann F, Henri S, Malissen B, Osborne LC, Artis D, Mowat AM.

Nat Immunol. 2014 Aug 24. doi: 10.1038/ni.2967.

The normal intestine contains large numbers of macrophages that play crucial roles in homeostasis, […]

Transcription Factor T Bet Regulates Lymphocyte Maturation

Transcription Factor T-bet Regulates Intraepithelial Lymphocyte Functional Maturation

Reis BS, Hoytema van Konijnenburg DP, Grivennikov SI, Mucida D.

Immunity. 2014 Aug 21;41(2):244-56. doi: 10.1016/j.immuni.2014.06.017.

IELs police the single-cell layer of intestinal epithelium, a fine boundary that spans as much as 400 square meters and allows nutrients in and wastes out. Nearly all IELs belong to a group […]

Transcription Factor T Bet is Induced by IL-15

The Transcription Factor T Bet Is Induced by IL-15 and Thymic Agonist Selection and Controls CD8αα(+) Intraepithelial Lymphocyte Development

Klose CS, Blatz K, d’Hargues Y, Hernandez PP, Kofoed-Nielsen M, Ripka JF, Ebert K, Arnold SJ, Diefenbach A, Palmer E, Tanriver Y.

Immunity. 2014 Aug 21;41(2):230-43. doi: 10.1016/j.immuni.2014.06.018.

CD8αα(+) intraepithelial lymphocytes (IELs) are instrumental in maintaining the epithelial […]

Epigenetic Regulator UHRF1 Facilitates Proliferation of T Cells

The Epigenetic Regulator UHRF1 Facilitates the Proliferation and Maturation of Colonic Regulatory T Cells

Obata Y, Furusawa Y, Endo TA, Sharif J, Takahashi D, Atarashi K, Nakayama M, Onawa S, Fujimura Y, Takahashi M, Ikawa T, Otsubo T, Kawamura YI, Dohi T, Tajima S, Masumoto H, Ohara O, Honda K, Hori S, Ohno H, Koseki […]

Intraepithelial T Cells Drive into Unusual MHC Reactivities

αβT Cell Receptors Expressed by CD4(-)CD8αβ(-) Intraepithelial T Cells Drive Their Fate into a Unique Lineage with Unusual MHC Reactivities

Mayans S, Stepniak D, Palida SF, Larange A, Dreux J, Arlian BM, Shinnakasu R, Kronenberg M, Cheroutre H, Lambolez F.

Immunity. 2014 Aug 21;41(2):207-18. doi: 10.1016/j.immuni.2014.07.010. Epub 2014 Aug 14.

The development pathway and major histocompatibility complex […]