Unique Lamina Propria Stromal Cells

Unique Lamina Propria Stromal Cells Imprint the Functional Phenotype of Mucosal Dendritic Cells

Vicente-Suarez I, Larange A, Reardon C, Matho M, Feau S, Chodaczek G, Park Y, Obata Y, Gold R, Wang-Zhu Y, Lena C, Zajonc DM, Schoenberger SP, Kronenberg M, Cheroutre H.

Mucosal Immunol. 2014 Jun 18. doi: 10.1038/mi.2014.51

The featured article provides supporting evidence  that […]

Elevated T Cell Receptor Signaling Identifies a Thymic Precursor

Elevated T Cell Receptor Signaling Identifies a Thymic Precursor to the TCRαβ(+)CD4(-)CD8β(-) Intraepithelial Lymphocyte Lineage

McDonald BD, Bunker JJ, Ishizuka IE, Jabri B, Bendelac A.

Immunity. 2014 Aug 21;41(2):219-29. doi: 10.1016/j.immuni.2014.07.008. Epub 2014 Aug 14.

The developmental pathway that TCRαβ+CD8αα+ intestinal intraepithelial lymphocytes (here called unconventional iIEL) follow has long remained a mystery. In their recent paper, […]

By |August 25th, 2014|Categories: August 2014, Featured Papers||0 Comments

T Cell Activation by Transitory Neo-Antigens from Microbial Pathways

T Cell Activation by Transitory Neo-Antigens Derived from Distinct Microbial Pathways

Corbett AJ, Eckle SB, Birkinshaw RW, Liu L, Patel O, Mahony J, Chen Z, Reantragoon R, Meehan B, Cao H, Williamson NA, Strugnell RA, Van Sinderen D, Mak JY, Fairlie DP, Kjer-Nielsen L, Rossjohn J, McCluskey J.

Nature. 2014 May 15;509(7500):361-5. doi: 10.1038/nature13160. Epub 2014 […]

Differential Role of Dendritic Cells and Lymphoid Cells

Segmented Filamentous Bacteria Antigens Presented by Intestinal Dendritic Cells Drive Mucosal Th17 Cell Differentiation

Yoshiyuki Goto, Casandra Panea, Gaku Nakato, Anna Cebula, Carolyn Lee, Marta Galan Diez, Terri M. Laufer, Leszek Ignatowicz, and Ivaylo I. Ivanov.

Immunity. 2014 Apr 17;40(4):594-607. doi: 10.1016/j.immuni.2014.03.005. Epub 2014 Mar 27.

How commensal bacteria modulate mucosal T cell responses remains poorly understood. […]

By |June 13th, 2014|Categories: 2014 Featured Papers, April 2014||0 Comments

Paneth Cells as a Site of Origin for Intestinal Inflammation

Adolph TE, Tomczak MF, Niederreiter L, Ko HJ, Böck J, Martinez-Naves E, Glickman JN, Tschurtschenthaler M, Hartwig J, Hosomi S, Flak MB, Cusick JL, Kohno K, Iwawaki T, Billmann-Born S, Raine T, Bharti R, Lucius R, Kweon MN, Marciniak SJ, Choi A, Hagen SJ, Schreiber S, Rosenstiel P, Kaser A, Blumberg RS.

Nature. 2013 Nov […]

By |May 30th, 2014|Categories: 2014 Featured Papers, February 2014||0 Comments

Pellino3 Ubiqitnates RIP2 and Mediates NOD2

Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis

Yang S, Wang B, Humphries F, Jackson R, Healy ME, Bergin R, Aviello G, Hall B, McNamara D, Darby T, Quinlan A, Shanahan F, Melgar S, Fallon PG, Moynagh PN

Nat Immunol. 2013 Sep;14(9):927-36. doi: 10.1038/ni.2669. Epub 2013 Jul 28.

This manuscript discovers a new […]

By |May 30th, 2014|Categories: 2014 Featured Papers, March 2014||0 Comments

A Shigella Effector Dampens Inflammation

A Shigella Effector Dampens Inflammation by Regulating Epithelial Release of Danger Signal ATP Through Production of the Lipid Mediator PtdIns5P

Puhar A, Tronchère H, Payrastre B, Nhieu GT, Sansonetti PJ.

Immunity. 2013 Dec 12;39(6):1121-31. doi: 10.1016/j.immuni.2013.11.013.

This study showed that in intestinal epithelial cells enteric pathogens Shigella, Salmonella and enteropathogenic Escherichia coli (EPEC) induce rapid, regulated release […]

Increased Production of Retinoic Acid

Increased production of retinoic acid by intestinal macrophages contributes to their inflammatory phenotype in patients with Crohn’s disease

Sanders TJ, McCarthy NE, Giles EM, Davidson KL, Haltalli ML, Hazell S, Lindsay JO, Stagg AJ.

Gastroenterology. 2014 May;146(5):1278-88.e1-2. doi: 10.1053/j.gastro.2014.01.057. Epub 2014 Feb 4.

This study tested the hypothesis that the ability of human intestinal CD103+ dendritic cells […]

By |May 30th, 2014|Categories: 2014 Featured Papers, May 2014||0 Comments