SMI Mourns the Loss of Per Brandtzaeg

Professor Per Brandtzaeg passed away on September 11, 2016 at the age of 80. Per Brandtzaeg was an influential force in mucosal immunology and will be deeply missed. Read more on his contributions made to SMI.

By |September 13th, 2016|Categories: 2016, News, Uncategorized||1 Comment

Maternal IgG and IgA Antibodies Dampen Mucosal T Helper Cell

Maternal IgG and IgA Antibodies Dampen Mucosal T Helper Cell Responses in Early Life
Koch MA, Reiner GL, Lugo KA, Kreuk LS, Stanbery AG, Ansaldo E, Seher TD, Ludington WB, Barton GM.

Immediately following birth, the gastrointestinal tract is colonized by diverse microbial species. Establishing proper immune responses to these microbes is essential to ensure optimal […]

IgA Production Requires B Cell Interaction with Subepithelial

IgA Production Requires B Cell Interaction with Subepithelial Dendritic Cells in Peyer’s Patches
Reboldi A, Arnon TI, Rodda LB, Atakilit A, Sheppard D, Cyster JG.

Immunoglobulin A (IgA) induction primarily occurs in intestinal Peyer’s patches (PPs). However, the cellular interactions necessary for IgA class switching are poorly defined. Here we show that in mice, activated B […]

In vivo Imaging and Tracking of Host-Microbiota Interactions via Metabolic

In vivo Imaging and Tracking of Host-Microbiota Interactions via Metabolic Labeling of Gut Anaerobic Bacteria
Naama Geva-Zatorsky, David Alvarez, Jason E. Hudak, Nicola C. Reading, Deniz Erturk-Hasdemir, Suryasarathi Dasgupta, Ulrich H. von Andrian, and Dennis L. Kasper: Nat Med. 2015 Sep; 21(9): 1091–1100. Published online 2015 Aug 17. doi:  10.1038/nm.3929

“The intestine is densely populated by anaerobic […]

Group 2 Innate Lymphoid Cells Utilize the IRF4-IL-9

Group 2 Innate Lymphoid Cells Utilize the IRF4-IL-9 Module to Coordinate Epithelial Cell Maintenance of Lung Homeostasis
Mohapatra A, Van Dyken SJ, Schneider C, Nussbaum JC, Liang HE, Locksley RM

Group 2 innate lymphoid cells (ILC2s) in lung are among the initial cells that respond to allergen-provoking challenges, but how signals are integrated to mediate their […]

Dietary Antigens Limit Mucosal Immunity by Inducing

Dietary Antigens Limit Mucosal Immunity by Inducing Regulatory T Cells in the Small Intestine
Kwang Soon Kim, Sung-Wook Hong, Daehee Han, Jaeu Yi, Jisun Jung, Bo-Gie Yang, Jun Young Lee, Minji Lee, Charles D. Surh

The gastrointestinal organs are chronically exposed to massive amount of diverse enteric antigens (Ags), most derived from diet and intestinal microbes both of which are benign and beneficial to […]

Anticancer Immunotherapy by CTLA-4 Blockade Relies on

Anticancer Immunotherapy by CTLA-4 Blockade Relies on the Gut Microbiota

Marie Vétizou, Jonathan M. Pitt, Romain Daillère, Patricia Lepage, Nadine Waldschmitt, Caroline Flament, Sylvie Rusakiewicz, Bertrand Routy, Maria P. Roberti, Connie P. M. Duong, Vichnou Poirier-Colame, Antoine Roux, Sonia Becharef, Silvia Formenti, Encouse Golden, Sascha Cording, Gerard Eber, Andreas Schlitzer, Florent Ginhoux, Sridhar Mani, Takahiro […]

In Memoriam of Professor Delphine Parrott

Professor Delphine Mary Vera Parrott 1929-2016
Delphine Parrott passed away peacefully at home in London on January 17, 2016. Over the course of her career she made many outstanding contributions to immunology.

Delphine was a native of Dulwich in South London, and she graduated in 1949 with an honours degree in Physiology from Bedford College, University […]

By |January 28th, 2016|Categories: 2016, News, SMI Archives||0 Comments

Epithelial-Derived IL-18 Regulates Th17 Cell Differentiation

Epithelial-Derived IL-18 Regulates Th17 Cell Differentiation and Foxp3(+) Treg Cell Function in the Intestine

Harrison OJ, Srinivasan N, Pott J, Schiering C, Krausgruber T, Ilott NE, Maloy

Intestinal immune homeostasis is maintained through a constant molecular dialogue between commensal microbiota, intestinal tissue cells, and the mucosal immune system. Breakdown of this mutualistic relationship results in chronic pathologies […]

Mongersen, an Oral SMAD7 Antisense Oligonucleotide

Mongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohn’s Disease

 

 
Giovanni Monteleone, M.D., Ph.D., Markus F. Neurath, M.D., Ph.D., Sandro Ardizzone, M.D., Antonio Di Sabatino, M.D., Massimo C. Fantini, M.D., Ph.D., Fabiana Castiglione, M.D., Maria L. Scribano, M.D., Alessandro Armuzzi, M.D., Ph.D., Flavio Caprioli, M.D., Ph.D., Giacomo C. Sturniolo, M.D., Francesca Rogai, M.D., Ph.D., Maurizio Vecchi, […]