Epithelial-Derived IL-18 Regulates Th17 Cell Differentiation

Epithelial-Derived IL-18 Regulates Th17 Cell Differentiation and Foxp3(+) Treg Cell Function in the Intestine

Harrison OJ, Srinivasan N, Pott J, Schiering C, Krausgruber T, Ilott NE, Maloy

Intestinal immune homeostasis is maintained through a constant molecular dialogue between commensal microbiota, intestinal tissue cells, and the mucosal immune system. Breakdown of this mutualistic relationship results in chronic pathologies […]

Mongersen, an Oral SMAD7 Antisense Oligonucleotide

Mongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohn’s Disease

 

 
Giovanni Monteleone, M.D., Ph.D., Markus F. Neurath, M.D., Ph.D., Sandro Ardizzone, M.D., Antonio Di Sabatino, M.D., Massimo C. Fantini, M.D., Ph.D., Fabiana Castiglione, M.D., Maria L. Scribano, M.D., Alessandro Armuzzi, M.D., Ph.D., Flavio Caprioli, M.D., Ph.D., Giacomo C. Sturniolo, M.D., Francesca Rogai, M.D., Ph.D., Maurizio Vecchi, […]

Defining Human Dendritic Cell Progenitors by Multiparametric Flow Cytometry

Defining Human Dendritic Cell Progenitors by Multiparametric Flow Cytometry

G. Breton, J. Lee, K. Liu, M.C. Nussenzweig: Defining human dendritic cell progenitors by multiparametric flow cytometry. Nat Protoc. 2015 Sep;10(9):1407-22. PMC4607256.

Dendritic cells (DCs) play an important role in the maintenance of mucosal homeostasis and the induction of antigen-specific mucosal immune responses.  DCs develop from bone marrow from increasingly restricted but phenotypically well-defined progenitor […]

By |November 30th, 2015|Categories: 2015, News, Protocols, Publications, SMI Archives||0 Comments

Generating Human Intestinal Tissue from Pluripotent Stem Cells

Generating Human Intestinal Tissue from Pluripotent Stem Cells In Vitro

K.W. McCracken, J.C. Howell, J.M. Wells, J.R. Spence:  Generating human intestinal tissue from pluripotent stem cells in vitro.  Nat Protoc. 2011 Nov 10;6(12):1920-8. PMC3896236

Three-dimensional cultures of mucosal epithelial cells termed organoids are considered the most physiological models of primary epithelial cells in vitro and have […]

By |November 30th, 2015|Categories: 2015, News, Protocols, Publications, SMI Archives||0 Comments

ICMI 2015 Plenary Vidoes

Missed out on ICMI 2015? Watch the ICMI 2015 plenary videos on SMI’s Vimeo page.

By |November 20th, 2015|Categories: 2015, News||0 Comments

An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid

An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses

Teruyuki Sano, Wend Huang, Jason A. Hall, Yi Yang, Alessandra Chen, Samuel J. Gavzy, June-Yong Lee, Joshua W. Ziel, Emily R. Miraldi, Ana I. Damingos, Richard Bonneau and Dan R. Littman.

RORγt+ Th17 cells are important for mucosal defenses, but also contribute […]

Early Infancy Microbial and Metabolic Alterations Affect Risk of

Early Infancy Microbial and Metabolic Alterations Affect Risk of Childhood Asthma

Marie-Claire Arrieta, Leah T. Stiemsma, Pedro A. Dimitriu, Lisa Thorson, Shannon Russell,Sophie Yurist-Doutsch, Boris Kuzeljevic, Matthew J. Gold, Heidi M. Britton, Diana L. Lefebvre,Padmaja Subbarao, Piush Mandhane, Allan Becker, Kelly M. McNagny, Malcolm R. Sears, Tobias Kollmann, the CHILD Study Investigators, William W. Mohn, Stuart E. Turvey and B. Brett Finlay

Asthma currently affects over 300 million people worldwide and is the most […]

Member Spotlight

SMI’s Immediate Past President Ken Beagley, has recently been recognized by media outlets for his research on male koalas. This work is a collaboration between Dr. Beagley and Professor Steve Johnston at the University of Queensland. Dr. Beagley briefly explains their research, “We have found that male koalas, as many as 70% in our […]

By |September 30th, 2015|Categories: 2015, News||0 Comments

Functional Characterization of IgA-Targeted Bacterial Taxa

Functional Characterization of IgA-Targeted Bacterial Taxa from Undernourished Malawian Children that Produce Diet-Dependent Enteropathy

Andrew L. Kau, Joseph D. Planer, Jie Liu, Sindhuja Rao, Tanya Yatsunenko, Indi Trehan, Mark J. Manary, Ta-Chiang Liu, Thaddeus S. Stappenbeck, Kenneth M. Maleta, Per Ashorn, Kathryn G. Dewey, Eric R. Houpt, Chyi-Song Hsieh and Jeffrey I. Gordon

Understanding how the […]

Vitamin B12 Modulates the Transcriptome of the Skin

Vitamin B12 Modulates the Transcriptome of the Skin Microbiota in Acne Pathogenesis

Dezhi Kang, Baochen Shi, Marie C. Erfe, Noah Craft and Huiying Li.

Skin bacteria are thought to play an important role in the development of acne vulgaris, one of the most common skin diseases throughout the world. However, the bacterial pathogenesis mechanism has not […]