Member Spotlight

SMI’s Immediate Past President Ken Beagley, has recently been recognized by media outlets for his research on male koalas. This work is a collaboration between Dr. Beagley and Professor Steve Johnston at the University of Queensland. Dr. Beagley briefly explains their research, “We have found that male koalas, as many as 70% in our […]

By |September 30th, 2015|Categories: 2015, News||0 Comments

Functional Characterization of IgA-Targeted Bacterial Taxa

Functional Characterization of IgA-Targeted Bacterial Taxa from Undernourished Malawian Children that Produce Diet-Dependent Enteropathy

Andrew L. Kau, Joseph D. Planer, Jie Liu, Sindhuja Rao, Tanya Yatsunenko, Indi Trehan, Mark J. Manary, Ta-Chiang Liu, Thaddeus S. Stappenbeck, Kenneth M. Maleta, Per Ashorn, Kathryn G. Dewey, Eric R. Houpt, Chyi-Song Hsieh and Jeffrey I. Gordon

Understanding how the […]

Vitamin B12 Modulates the Transcriptome of the Skin

Vitamin B12 Modulates the Transcriptome of the Skin Microbiota in Acne Pathogenesis

Dezhi Kang, Baochen Shi, Marie C. Erfe, Noah Craft and Huiying Li.

Skin bacteria are thought to play an important role in the development of acne vulgaris, one of the most common skin diseases throughout the world. However, the bacterial pathogenesis mechanism has not […]

What has SMI been up to this year?

Would you like to know what SMI has been up to this year? Check out SMI Annual Report to learn more!

By |September 8th, 2015|Categories: 2015, News||0 Comments

A Mucosal Vaccine Against Chlamydia Trachomatis

A Mucosal Vaccine Against Chlamydia Trachomatis Generates Two Waves of Protective Memory T cells

Georg Stary, Andrew Olive, Aleksandar F. Radovic-Moreno, David Gondek, David Alvarez, Pamela A. Basto, Mario Perro, Vladimir D. Vrbanac, Andrew M. Tager, Jinjun Shi, Jeremy A. Yethon, Omid C. Farokhzad, Robert Langer, Michael N. Starnbach, Ulrich H. von Andrian

Science. 2015 Jun 19;348(6241):aaa8205. doi: 10.1126/science.aaa8205.

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Interferon-λ and Interleukin 22 Act Synergistically

Interferon-λ and Interleukin 22 Act Synergistically for the Induction of Interferon-Stimulated Genes and Control of Rotavirus Infection

Pedro P Hernández, Tanel Mahlakõiv, Ines Yang, Vera Schwierzeck, Nam Nguye,
Fabian Guendel, Konrad Gronke, Bernhard Ryffel, Christoph Hölscher, Laure Dumoutier, Jean-Christophe Renauld, Sebastian Suerbaum, Peter Staeheli & Andreas Diefenbach

Nat Immunol. 2015 Jul;16(7):698-707. doi: 10.1038/ni.3180. Epub 2015 May 25.

 

 

 

 

 

Emerging […]

Vertically Transmitted Fecal IgA Levels Determine Phenotypic Variation

Vertically Transmitted Fecal IgA Levels Determine Extra-Chromosomal Phenotypic Variation

Moon C, Baldridge MT, Wallace MA, Burnham CA, Virgin HW, Stappenbeck TS.

Nature. 2015 Feb 16. doi: 10.1038/nature14139. [Epub ahead of print]

Phenotypic variation between apparently genetically identical mice at different facilities/institutions has been a challenge facing investigators working in many different murine experimental systems. Differences in commensal […]

By |May 1st, 2015|Categories: 2015, 2015 Featured Papers, April 2015, News||0 Comments

Grand Challenges Explorations (GCE) Applications

Grand Challenges Explorations (GCE) has opened application Round 15, and proposals for the six topics listed below are being accepted online through May 13, 2015.

GCE Round 15 topics:
• Addressing Newborn and Infant Gut Health Through Bacteriophage-Mediated Microbiome Engineering
• Explore New Ways to Measure Delivery and Use of Digital Financial Services Data
• Surveillance […]

By |March 23rd, 2015|Categories: 2015, News||0 Comments

Commensal Gram-positive Bacteria Initiate Colitis

Commensal Gram-positive Bacteria Initiates Colitis by Inducing Monocyte/Macrophage Mobilization

Y Nakanishi, T Sato and T Ohteki.

Mucosal Immunology (2015) 8, 152–160; doi:10.1038/mi.2014.53; published online 18 June 2014

The commensal bacteria in the intestine benefit the host immune response. However, breakdown of the intestinal epithelial layer’s barrier function results in the inflow of commensal flora and improper immune […]

MyD88 Signaling in T Cells Directs IgA-Mediate Control of Microbiota

MyD88 Signaling in T Cells Directs IgA-Mediated Control of the Microbiota to Promote Health

Jason L. Kubinak, Charisse Petersen, W. Zac Stephens, Ray Soto, Erin Bake, Ryan M. O’Connell, June L. Round.

http://dx.doi.org/10.1016/j.chom.2014.12.009

Alterations to the commensal communities on our bodies can lead to disease, however the mechanisms by which the host can control and sculpt the […]