SMI Archives

Anticancer Immunotherapy by CTLA-4 Blockade Relies on

Anticancer Immunotherapy by CTLA-4 Blockade Relies on the Gut Microbiota

Marie Vétizou, Jonathan M. Pitt, Romain Daillère, Patricia Lepage, Nadine Waldschmitt, Caroline Flament, Sylvie Rusakiewicz, Bertrand Routy, Maria P. Roberti, Connie P. M. Duong, Vichnou Poirier-Colame, Antoine Roux, Sonia Becharef, Silvia Formenti, Encouse Golden, Sascha Cording, Gerard Eber, Andreas Schlitzer, Florent Ginhoux, Sridhar Mani, Takahiro […]

In Memoriam of Professor Delphine Parrott

Professor Delphine Mary Vera Parrott 1929-2016
Delphine Parrott passed away peacefully at home in London on January 17, 2016. Over the course of her career she made many outstanding contributions to immunology.

Delphine was a native of Dulwich in South London, and she graduated in 1949 with an honours degree in Physiology from Bedford College, University […]

By |January 28th, 2016|Categories: 2016, News, SMI Archives||0 Comments

Epithelial-Derived IL-18 Regulates Th17 Cell Differentiation

Epithelial-Derived IL-18 Regulates Th17 Cell Differentiation and Foxp3(+) Treg Cell Function in the Intestine

Harrison OJ, Srinivasan N, Pott J, Schiering C, Krausgruber T, Ilott NE, Maloy

Intestinal immune homeostasis is maintained through a constant molecular dialogue between commensal microbiota, intestinal tissue cells, and the mucosal immune system. Breakdown of this mutualistic relationship results in chronic pathologies […]

Mongersen, an Oral SMAD7 Antisense Oligonucleotide

Mongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohn’s Disease

 

 
Giovanni Monteleone, M.D., Ph.D., Markus F. Neurath, M.D., Ph.D., Sandro Ardizzone, M.D., Antonio Di Sabatino, M.D., Massimo C. Fantini, M.D., Ph.D., Fabiana Castiglione, M.D., Maria L. Scribano, M.D., Alessandro Armuzzi, M.D., Ph.D., Flavio Caprioli, M.D., Ph.D., Giacomo C. Sturniolo, M.D., Francesca Rogai, M.D., Ph.D., Maurizio Vecchi, […]

Defining Human Dendritic Cell Progenitors by Multiparametric Flow Cytometry

Defining Human Dendritic Cell Progenitors by Multiparametric Flow Cytometry

G. Breton, J. Lee, K. Liu, M.C. Nussenzweig: Defining human dendritic cell progenitors by multiparametric flow cytometry. Nat Protoc. 2015 Sep;10(9):1407-22. PMC4607256.

Dendritic cells (DCs) play an important role in the maintenance of mucosal homeostasis and the induction of antigen-specific mucosal immune responses.  DCs develop from bone marrow from increasingly restricted but phenotypically well-defined progenitor […]

By |November 30th, 2015|Categories: 2015, News, Protocols, Publications, SMI Archives||0 Comments

Generating Human Intestinal Tissue from Pluripotent Stem Cells

Generating Human Intestinal Tissue from Pluripotent Stem Cells In Vitro

K.W. McCracken, J.C. Howell, J.M. Wells, J.R. Spence:  Generating human intestinal tissue from pluripotent stem cells in vitro.  Nat Protoc. 2011 Nov 10;6(12):1920-8. PMC3896236

Three-dimensional cultures of mucosal epithelial cells termed organoids are considered the most physiological models of primary epithelial cells in vitro and have […]

By |November 30th, 2015|Categories: 2015, News, Protocols, Publications, SMI Archives||0 Comments