Increased production of retinoic acid by intestinal macrophages contributes to their inflammatory phenotype in patients with Crohn’s disease

Sanders TJ, McCarthy NE, Giles EM, Davidson KL, Haltalli ML, Hazell S, Lindsay JO, Stagg AJ.

Gastroenterology. 2014 May;146(5):1278-88.e1-2. doi: 10.1053/j.gastro.2014.01.057. Epub 2014 Feb 4.

Left to Right: Neil McCarthy, Andrew Stagg, Ed Giles, Theo Sanders, James Lindsay

Left to Right: Neil McCarthy, Andrew Stagg, Ed Giles, Theo Sanders, James Lindsay

This study tested the hypothesis that the ability of human intestinal CD103+ dendritic cells (DCs) to generate the important immunoregulatory molecule retinoic acid (RA) is reduced in patients with Crohn’s disease compared with healthy controls, as suggested by mouse models of experimental intestinal inflammation. Contrary to expectation, an increased proportion of CD103+ DCs as well as CD14+ macrophages (MΦ) displayed an ability to generate RA in Crohn’s disease patients. Signalling through the RA receptor was required for the in vitro differentiation of monocytes. PMID:24503130