By Andreas Baumler & Vanessa Sperandio

The microbiome plays an important role in human health.

Recent studies highlight that microbiota changes can confer resistance or promote infection by bacterial pathogens. Antibiotics have profound impacts on the microbial community, therefore altering the nutritional landscape in the gut, which can lead to pathogen expansion. Pathogens exploit microbiota-derived carbon and nitrogen sources as both nutrients and/or regulatory signals to promote growth and/or virulence. By eliciting inflammation, pathogens can alter the intestinal environment and utilize unique respiratory and metal acquisition systems to drive their expansion. Unraveling these pathogen-microbiota-host interactions will lead to novel therapeutic microbiota manipulation strategies against infectious diseases.

Read more in: Bäumler AJ, Sperandio V. Interactions between the microbiota and pathogenic bacteria in the gut. Nature. 2016 Jul 7; 535(7610):85-93. doi: 10.1038/nature18849.

Links to Authors’ List of Publications:

Andreas Baumler: http://www.ncbi.nlm.nih.gov/pubmed/?term=baumler+aj

Vanessa Sperandio: https://www.ncbi.nlm.nih.gov/pubmed/?term=Sperandio+V