MyD88 Signaling in T Cells Directs IgA-Mediated Control of the Microbiota to Promote Health

Jason L. Kubinak, Charisse Petersen, W. Zac Stephens, Ray Soto, Erin Bake, Ryan M. O’Connell, June L. Round.

Round - MyD88

Left to Right: Jason L. Kubinak, June L. Round and Charisse Peterson

Alterations to the commensal communities on our bodies can lead to disease, however the mechanisms by which the host can control and sculpt the microbiota remain unknown. This study has identified a signaling pathway within T cells that integrates microbial cues to control the microbiota. While typically considered an innate molecule, Kubinak et. al. show that MyD88 signaling in cells of the adaptive immune system, T cells,  coordinates antibody responses directed against commensal microbes by promoting T follicular helper cell development. Loss of this pathway results in abnormal IgA binding of bacteria and an altered microbial community in the gut that predisposes individuals to more severe inflammatory disease.  More importantly, intestinal disease can be rescued with a fecal transplant from a healthy donor.  These data identify a novel pathway that functions to sculpt a healthy microbiota to maintain homeostasis.

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