Featured Papers

Lung Epithelial Cells Coordinate Innate Lymphocytes and Immunity against Pulmonary Fungal Infection 

Nydiaris Hernandez-Santos, Darin L. Wiesner, J. Scott Fites, Andrew J. McDermott, Thomas Warner, Marcel W€uthrich, Bruce S. Klein.

Lung Epithelial Cells Coordinate Innate Lymphocytes and Immunity against Pulmonary Fungal Infection 

In this featured paper, Hernandez-Santos et al. show that the lung epithelium guards against inhaled
fungi by providing early signals that orchestrate innate immunity.

Lung epithelial cells (LECs) are strategically positioned in the airway mucosa […]

Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia

By Pankaj Baral, Benjamin D Umans, Lu Li, Antonia Wallrapp, Meghna Bist, Talia Kirschbaum, Yibing Wei, Yan Zhou, Vijay K Kuchroo, Patrick R Burkett, Bryan G Yipp, Stephen D Liberles & Isaac M Chiu.

Nature Medicine: Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia

This featured article emphasizes […]

Proliferation of Ly6C+ monocytes regulated by IL-6

By Dixit, Bottek, Beerlage, Schuettpelz, Thiebes, Brenzel, Garbers, Rose-John, Mittrücker, Squire and Engel.

Frontline Science: Proliferation of Ly6C+ monocytes during urinary tract infections is regulated by IL-6 trans-signaling.

This interesting publication highlighted in the January edition of the Journal of Leukocyte Biology focuses on mucosal immune responses in urinary tract infection. Specifically, the team around Dixit and […]

Innate and adaptive lymphocytes sequentially shape the gut microbiota and lipid metabolism

By Kairui Mao, Antonio P. Baptista, Samira Tamoutounour, Lenan Zhuang, Nicolas Bouladoux, Andrew J. Martins, Yuefeng Huang, Michael Y. Gerner, Yasmine Belkaid & Ronald N. Germain

Innate and adaptive lymphocytes sequentially shape the gut microbiota and lipid metabolism.

The recent paper published by Mao et al. describes new insight about the interaction of the innate and adaptive […]

Effects of a gut pathobiont in a gnotobiotic mouse model of childhood undernutrition

By Vitas E. Wagner, Neelendu Dey, Janaki Guruge, Ansel Hsiao, Philip P. Ahern, Nicholas P. Semenkovich, Laura V. Blanton, Jiye Cheng, Nicholas Griffin, Thaddeus S. Stappenbeck, Olga Ilkayeva, Christopher B. Newgard, William Petri, Rashidul Haque, Tahmeed Ahmed and Jeffrey I. Gordon

Childhood undernutrition is a pressing global health challenge.

Children with moderate or severe undernutrition exhibit […]

Interactions between the microbiota and pathogenic bacteria in the gut

By Andreas Baumler & Vanessa Sperandio

The microbiome plays an important role in human health.

Recent studies highlight that microbiota changes can confer resistance or promote infection by bacterial pathogens. Antibiotics have profound impacts on the microbial community, therefore altering the nutritional landscape in the gut, which can lead to pathogen expansion. Pathogens exploit microbiota-derived carbon […]

Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species

By Guilliams M, Dutertre CA, Scott CL, McGovern N, Sichien D, Chakarov S, Van Gassen S, Chen J, Poidinger M, De Prijck S, Tavernier SJ, Low I, Irac SE, Mattar CN, Sumatoh HR, Low G, Chung J, Chan D, Tan KK, Tony Lim KH, Fossum E, Bogen B, Choolani M, Chan J, Larbi A, […]

Secretory leukoprotease inhibitor is required for efficient quercetin-mediated suppression of TNFα secretion

Stefania De Santis, Dale Kunde, Grazia Serino, Vanessa Galleggiante, Maria Lucia Caruso, Mauro Mastronardi, Elisabetta Cavalcanti, Nicole Ranson, Aldo Pinto, Pietro Campiglia, Angelo Santino, Rajaraman Eri, Marcello Chieppa

Our data encourages the development of nutritional strategies to improve the efficiency of current therapies for intestinal chronic inflammatory syndrome and reduce the risks of colorectal cancer […]

By |January 19th, 2017|Categories: Featured Papers, January 2017|Tags: , , , , |0 Comments

Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments

Rafael Di Marco Barros, Natalie A. Roberts, Robin J. Dart, Pierre Vantourout, Anett Jandke,
Oliver Nussbaumer, Livija Deban, Sara Cipolat, Rosie Hart, Maria Luisa Iannitto, Adam Laing,
Bradley Spencer-Dene, Philip East, Deena Gibbons, Peter M. Irving, Pablo Pereira, Ulrich Steinhoff,
and Adrian Hayday

A conserved biology emerges linking mucosal and skin intraepithelial lymphocyte (IEL) biology and mucosal IEL […]

IL-33 regulates the IgA-microbiota axis to restrain IL-1α–dependent colitis and tumorigenesis

Ankit Malik, Deepika Sharma, Qifan Zhu, Rajendra Karki, Clifford S. Guy, Peter Vogel, and Thirumala-Devi Kanneganti

Inflammatory bowel diseases (IBD) affect over 5 million individuals in the industrialized world, with an increasing incidence rate worldwide. IBD also predisposes affected individuals to development of colorectal cancer, which is a leading cause of cancer-related deaths in adults. […]