Featured Papers

Interferon-λ and Interleukin 22 Act Synergistically

Interferon-λ and Interleukin 22 Act Synergistically for the Induction of Interferon-Stimulated Genes and Control of Rotavirus Infection

Pedro P Hernández, Tanel Mahlakõiv, Ines Yang, Vera Schwierzeck, Nam Nguye,
Fabian Guendel, Konrad Gronke, Bernhard Ryffel, Christoph Hölscher, Laure Dumoutier, Jean-Christophe Renauld, Sebastian Suerbaum, Peter Staeheli & Andreas Diefenbach

Nat Immunol. 2015 Jul;16(7):698-707. doi: 10.1038/ni.3180. Epub 2015 May 25.

 

 

 

 

 

Emerging […]

Vertically Transmitted Fecal IgA Levels Determine Phenotypic Variation

Vertically Transmitted Fecal IgA Levels Determine Extra-Chromosomal Phenotypic Variation

Moon C, Baldridge MT, Wallace MA, Burnham CA, Virgin HW, Stappenbeck TS.

Nature. 2015 Feb 16. doi: 10.1038/nature14139. [Epub ahead of print]

Phenotypic variation between apparently genetically identical mice at different facilities/institutions has been a challenge facing investigators working in many different murine experimental systems. Differences in commensal […]

By |May 1st, 2015|Categories: 2015, 2015 Featured Papers, April 2015, News|Tags: |0 Comments

Commensal Gram-positive Bacteria Initiate Colitis

Commensal Gram-positive Bacteria Initiates Colitis by Inducing Monocyte/Macrophage Mobilization

Y Nakanishi, T Sato and T Ohteki.

Mucosal Immunology (2015) 8, 152–160; doi:10.1038/mi.2014.53; published online 18 June 2014

The commensal bacteria in the intestine benefit the host immune response. However, breakdown of the intestinal epithelial layer’s barrier function results in the inflow of commensal flora and improper immune […]

By |February 12th, 2015|Categories: 2015, 2015 Featured Papers, Featured Papers, February 2015, News|Tags: |0 Comments

Species-specific Expression of Colon T Cell Homing

Role and Species-specific Expression of Colon T Cell Homing Receptor GPR15 in Colitis

Nguyen LP, Pan J, Dinh TT, Hadeiba H, O’Hara E 3rd, Ebtikar A, Hertweck A, Gökmen MR, Lord GM, Jenner RG, Butcher EC, Habtezion A.

Nat Immunol. 2015 Feb;16(2):207-13. doi: 10.1038/ni.3079. Epub 2014 Dec 22.

Recruitment of lymphocytes from circulation is a tissue- and […]

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Interleukin (IL)-21 Promotes Intestinal IgA Responses to Microbiota

Interleukin (IL)-21 Promotes Intestinal IgA Responses to Microbiota

Cao AT, Yao S, Gong B, Nurieva RI, Elson CO, Cong Y.

Mucosal Immunol. 2015 Jan 14. doi: 10.1038/mi.2014.134.

The intestinal tract is colonized by trillions of commensal bacteria that live in a mutualistic relationship our bodies. Commensal microbiota-specific Th17 cells are enriched in the intestines and are crucial […]

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MyD88 Signaling in T Cells Directs IgA-Mediate Control of Microbiota

MyD88 Signaling in T Cells Directs IgA-Mediated Control of the Microbiota to Promote Health

Jason L. Kubinak, Charisse Petersen, W. Zac Stephens, Ray Soto, Erin Bake, Ryan M. O’Connell, June L. Round.

http://dx.doi.org/10.1016/j.chom.2014.12.009

Alterations to the commensal communities on our bodies can lead to disease, however the mechanisms by which the host can control and sculpt the […]

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Commensal-dendritic-cell Interaction Immune Signature

Commensal-dendritic-cell Interaction Specifies a Unique Protective Skin Immune Signature

Naik S, Bouladoux N, Linehan JL, Han SJ, Harrison OJ, Wilhelm C, Conlan S, Himmelfarb S, Byrd AL, Deming C, Quinones M, Brenchley JM, Kong HH, Tussiwand R, Murphy KM, Merad M, Segre JA, Belkaid Y.

Nature 2015 Jan5. Doi: 10.1038/nature14052

As the largest organ of the body, […]

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Novel Mucosal Vaccine Targeting Peyer’s Patch M Cells

A Novel Mucosal Vaccine Targeting Peyer’s Patch M Cells Induces Protective Antigen-Specific IgA Responses

Shima H, Watanabe T, Fukuda S, Fukuoka S, Ohara O, Ohno H.

Int Immunol. 2014 Nov;26(11):619-25. doi: 10.1093/intimm/dxu061. Epub 2014 Jun 7.

Glycoprotain 2 (GP2) is a bacterial uptake receptor on M cells, a unique subset of intestinal epithelial cells specialized for efficient […]

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Cutting Edge: GPR35/CXCR8 is the Receptor of CXCL17

Cutting Edge: GPR35/CXCR8 is the Receptor of the Mucosal Chemokine CXCL17

Maravillas-Montero JL, Burkhardt AM, Hevezi PA, Carnevale CD, Smit MJ, Zlotnik A.

J Immunol. 2014 Nov 19. pii: 1401704. [Epub ahead of print]

Chemokines control the migration and homing of hematopoietic cells in the body. The last chemokine to be described was CXCL17, which exhibits a […]

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Indigenous Enteric Eosinophils Control DCs

Indigenous Enteric Eosinophils Control DCs to Initiate a Primary Th2 Immune Response in vivo

Chu DK, Jimenez-Saiz R, Verschoor CP, Walker TD, Goncharova S, Llop-Guevara A, Shen P, Gordon ME, Barra NG, Bassett JD, Kong J, Fattouh R, McCoy KD, Bowdish DM, Erjefält JS, Pabst O, Humbles AA, Kolbeck R, Waserman S, Jordana M.

J Exp […]

By |December 15th, 2014|Categories: 2014 Featured Papers, December 2014, Featured Papers|Tags: |0 Comments