Unique Lamina Propria Stromal Cells Imprint the Functional Phenotype of Mucosal Dendritic Cells

Vicente-Suarez I, Larange A, Reardon C, Matho M, Feau S, Chodaczek G, Park Y, Obata Y, Gold R, Wang-Zhu Y, Lena C, Zajonc DM, Schoenberger SP, Kronenberg M, Cheroutre H.

Mucosal Immunol. 2014 Jun 18. doi: 10.1038/mi.2014.51

Vicente-Suarez Photo

Cheroutre’s and Kronenberg’s Lab

The featured article provides supporting evidence  that stromal cells (SCs) and dendritic cells (DCs) are engaged in an active cross-talk within the intestinal lamina propria (LP) that might shape both cell types. During this study the authors characterized a unique LP SC population able to imprint DCs with the capacity to produce retinoic acid (RA) a vitamin A metabolite shown to play a fundamental role in immuneregulation. This imprinting depended on the ability of the SCs themselves to produce RA together with GM-CSF. Most interestingly, GM-CSF production by SCs was regulated by the presence of DCs while their ability to produce RA might depend on the intestinal microbiota. This work supports a paradigm in which immune cell behavior might be deeply influenced by the SC subsets present in their tissue of residence and furthermore the shaping activity of these SCs might be derived from their capacity to interpret environmental cues. PubMed:24938743