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Putin may be on to something...


Russia's president Vladimir Putin reportedly participated in a trial for an intranasal COVID-19 vaccine booster to improve mucosal protection from SARS-CoV-2. A recent study in mice, published last week in Nature Communications, also supports a mucosal booster strategy to enhance protection from SARS-CoV-2. Lapuente, Tenbusch and colleagues demonstrated that intranasal boosts with adenoviral vectors following an initial systemic mRNA vaccine induce high levels of mucosal IgA and lung-resident memory T cells with increased mucosal neutralization of SARS-CoV-2 including virus variants of concern.

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  • Immune & Epithelial Interactions
  • Mucosal Infections