Postdoc in Mucosal Immunology

Posted On
September 28, 2022

Institution
Division of Experimental and Translational Immunology, Department of Health Technology, Technical University of Denmark

Position Title

Organization Description
We are looking for 1-2 highly motivated postdoctoral fellows to join the Mucosal Immunology Group headed by Professor William Agace at the Division of Experimental and Translational Immunology, Department of Health Technology, Technical University of Denmark. The successful candidate will join a superb team of international researchers within the newly established NovoNordisk Foundation challenge grant-funded ‘Center for Intestinal Immune Regulation (CIIR)’. CIIR comprises of 4 collaborating teams (Agace, DTU; McCoy, Calgary (Canada); Bendtsen, Hvidovre hospital; Rønn-Larsen, DTU) whose combined expertise in mucosal immunology, gastroenterology, microbiota-host interactions, bioinformatics and state-of-the-art animal models aims to identify intestinal immune-stromal interactions important in intestinal homeostasis and in inflammatory bowel disease (IBD). In joining you will be part of a highly vibrant and cross-disciplinary team of researchers at the international forefront of mucosal immunology research.

Responsibilities and qualifications
Your project is to identify immune-stromal interactions that are important for maintaining intestinal immune homeostasis and in the setting of inflammation promote immune mediated pathology. For this you will utilize state-of-the-art transgenic mouse models to modulate intestinal stromal-immune interactions and assess downstream consequences on intestinal homeostasis and disease (the latter using infection/inflammation models). You will combine the above with scRNA-seq, CITE-seq, and spatial proteomics/transcriptomics analysis as well as in vitro co-culture techniques to perform mode of action studies. The project is multi-disciplinary and will involve close collaborations with participating bioinformaticians as well as researchers analyzing human intestinal immune compartments in health and IBD. The work is also expected to include some teaching and/or supervision of students within the laboratory.

You must hold a PhD degree or equivalent in immunology, be highly motivated, have the ability to work independently but also enjoy contributing and working within a team. The successful candidates will have documented experience in mucosal immunology, working with transgenic animal models, mouse colony maintenance and in depth analysis of murine intestinal tissues including cell isolation, multi-color flow cytometry and cell sorting and intestinal disease models. Additional experience with spatial transcriptomics/proteomics scRNA-seq and organ cultures will be considered a merit.

We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

Salary and terms of employment
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union.
The period of employment is 3 years full time with a starting date of 1 January 2023 (or according to mutual agreement)

You can read more about career paths at DTU here.

Further information
Further information please contact William Agace (wiag@dtu.dk).

Home page: Experimental and Translational Immunology research group

If you are applying from abroad, you may find useful information on working in Denmark and at DTU at DTU – Moving to Denmark.