Live & On-Demand
The Society for Mucosal Immunology provides live webinars for member and non-member participation focused on the latest ideas and concepts of immunity at mucosal surfaces. Registration and access to the on-demand webinar recording library is free to all SMI members. Non-members are invited to join us for the live webinar at a nominal registration rate of $25/webinar.
2021 Webinar Series Co-chairs
Katharina Lahl, PhD - Technical University of Denmark
Rodney Newberry, MD - Washington University School of Medicine
Lauren A. Zenewicz, PhD - The University of Oklahoma Health Sciences Center
How To View
All registrants will receive the login instructions at the email address used to register in advance of the webinar session.
Members can access the on-demand webinar library through the member login portal.
Registration for each webinar session is separate and linked to in the below webinar description. Members access the free member registration rate by first signing in to the SMI website.
Thursday, June 24, 2021 – 11:00 am CT
Innate Mucosal Immunity
William Agace, PhD, Lund University
Elizabeth Mann, PhD, The University of Manchester
William Agace is professor and head of the Immunology Section at Lund University, Sweden and a professor at the Department of Health Technology, Technical University of Denmark. He has been working in field of mucosal immunology for over 25 years. His research activities have focused primarily on (1) the cellular mechanism regulating lymphocyte trafficking to the intestinal mucosa, including the identification of CCR9 as a small intestinal homing receptor, (2) the role of dendritic cells in the generation of gut tropic T cells, including the identification and function of CD103+ dendritic cells (cDC) and (3) intestinal antigen presenting cell heterogeneity and function, including the importance of cDC2 in intestinal Th17 immunity and cDC1 in Th1 immunity and intraepithelial lymphocyte homeostasis. More recently his laboratory has developed novel techniques for the identification, isolation and analysis of human gut associated lymphoid tissues (GALT) including mucosal and submucosal isolated lymphoid follicles. His research has over the years resulted in several awards including the Anders Jahre prize in biomedicine (Oslo University) and the Göran Gustafsson prize from the Swedish Royal Academy of Science, in which he has served as an elected member since 2019 He has been actively involved in the Society of Mucosal Immunology (SMI) for many years, including acting as 1 of 3 Chief-Editors for the Society’s journal Mucosal Immunology, as a European Counselor on the SMI board and currently as President-Elect.
The intestinal mucosa contains two major conventional dendritic cell (cDC) subsets, cDC1 and cDC2 that we, and others, have shown to play distinct non-redundant roles in intestinal immune homeostasis. Thus, while cDC1 appear important for mucosal Th1 responses and the establishment of the intestinal intraepithelial lymphocyte compartment, cDC2 are important for the generation of intestinal Th17 cells and in mucosal Th2 responses. Here I will discuss our recent findings demonstrating a key role for intestinal cDC1 in cross tolerance to intestinal epithelial cell (IEC)-derived antigen. Strikingly, intestinal cDC1 dependent cross-tolerance involved the generation and suppressive function of FoxP3+CD8+ T cells and absence of either cDC1 or FoxP3+CD8+ T cells lead to a break of tolerance and IEC destruction. Mechanistically, intestinal cDC1-derived PD-L1, TGFb and retinoic acid contributed to the generation of ‘gut tropic’ CCR9+CD103+FoxP3+CD8+ Treg cells. Finally we found that CD103 deficient CD8+ T cells lacked tolerogenic activity in vivo, indicating a role for CD103 in FoxP3+CD8+ Treg function. Our results highlight a novel role for cDC1 in the generation of FoxP3+CD8+ T cells, that we speculate may be unique to the intestinal environment.
Elizabeth Mann completed by PhD in Immunology in 2010 from Imperial College London, studying tissue-specificity of human dendritic cells in the lab of Stella Knight. Her postdoctoral studies at Johns Hopkins University in Baltimore with Xuhang Li, and the University of Glasgow with Simon Milling investigated how intestinal immune responses are dysregulated in inflammatory bowel disease, and how gut immunity is shaped by local factors including the gut microbiota. She established her own research group in 2017 through a Welcome Trust and Royal Society-funded Henry Dale Fellowship based on this research. Dr. Mann’s current research addresses how mucosal immune responses and in particular macrophages are regulated by the local environment in the intestine, the lungs and the reproductive tract.
Proliferation, differentiation and shedding of the endometrium (uterus lining) in health require precise coordination of tissue degradation, clearance of debris and tissue remodeling. In other tissues, the innate immune system is central to tissue remodeling and repair with macrophages in particular phagocytosing cellular debris and acting as regulators and effectors of the complex pro- and anti-inflammatory responses that determine tissue integrity. When this process becomes dysregulated, the sustained inflammatory environment and disruption in tissue remodeling can lead to structural abnormalities that contribute to infertility and miscarriage. However, the immune system in the female reproductive tract is poorly characterized compared to other mucosal tissues such as the intestine and lungs, which has led to limited treatment options for reproductive diseases. I will present data demonstrating the specialized properties and functions of macrophages in the uterus in mice, and I will also present human data from collaboration with the Reproductive Medicine department within Manchester University NHS Foundation Trust.
Thursday, September 23, 2021 – 11:00 am CT
Host-pathogen Interactions at Mucosal Surfaces
Marc Lecuit, MD, PhD, Institut Pasteur
Venessa Sperandio, PhD, UT Southwestern Medical
Thursday, October 21, 2021 – Time: TBD
Upper Aerodigestive Tract Immunity
Noam Cohen, MD, PhD, University of Pennsylvania
Niki Moutsopoulos, DDS, PhD, NIH
Thursday, November 18, 2021 – 11:00 am CT
Immunoglobulin Responses to Mucosal Microbes
Emma Slack, PhD, ETH Zurich
Xin Luo, PhD, Virginia-Maryland College of Veterinary Medicine
Past Recorded Webinars
MOLECULAR AND CELLULAR DISSECTION OF THE NEW FOOD ALLERGY DISEASE EOSINOPHILIC ESOPHAGITIS
Marc Rothenberg, MD, PhD
July 14, 2020
REGULATORY NATURAL KILLER CELL RESPONSES SHAPE THE OUTCOME OF CO-INFECTION BY LUNG AND GUT PATHOGENS
Laurel L. Lenz, PhD
August 11, 2020
INJURY AND REPAIR OF THE ALVEOLAR EPITHELIAL BARRIER
By Rachel Zemans, MD
September 1st, 2020
MUCOSAL THERAPIES: RESOLUTION RESPONSES IN ORAL CAVITY
By Thomas Van Dyke DDS, PhD
September 15th, 2020
HARNESSING THE MICROBIOME FOR IBD THERAPY
By Ramnik Xavier MD, PhD
November 10th, 2020
ABSTRACT ORAL PRESENTATION WEBINARS - MICROBIOTA
November 12th, 2020
ABSTRACT ORAL PRESENTATION WEBINARS - ADAPTIVE IMMUNITY
November 17th, 2020
ABSTRACT ORAL PRESENTATION WEBINARS - MECHANISMS OF INFLAMMATION
November 19th, 2020
ABSTRACT ORAL PRESENTATION WEBINARS - MUCOSAL IMMUNOBIOLOGY
November 24th, 2020
ABSTRACT ORAL PRESENTATION WEBINARS - MUCOSAL COLONIZATION
December 1st, 2020
ABSTRACT ORAL PRESENTATION WEBINARS - HOST-MICROBE INTERACTIONS
December 3rd, 2020
Webinar Series Live & On-Demand - Mucosal Epithelial Cells
March 16th, 2021
Webinar Series Live & On-Demand - ILCs and IELs
May 20th, 2021