Granzyme A is pro-inflammatory in colorectal cancer development

A new study by Julian Pardo and colleagues published in Cell Reports @CellReports shows that the cytotoxic protease Granzyme A actually promotes, rather than inhibits, cancer and inflammation in the gut. Indeed therapeutic inhibiton of Granzyme A could also reduce colorectal cancer development in mice, suggesting that Granzyme A may be a useful target for treating cancer and gut inflammation.