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Tissue clonality of dendritic cell subsets and emergency DCpoiesis revealed by multicolor fate mapping of DC progenitors


Mar Cabeza-Cabrerizo, Janneke van Blijswijk, Stephan Wienert, Daniel Heim, Robert P. Jenkins, Probir Chakravarty, Neil Rogers, Bruno Frederico, Sophie Acton1, Evelyne Beerling, Jacco van Rheenen, Hans Clevers, Barbara U. Schraml, Marc Bajénoff, Michael Gerner, Ronald N. Germain, Erik Sahai, Frederick Klauschen and Caetano Reis e Sousa.

Conventional dendritic cells (cDCs) are found in all tissues and play a key role in immune surveillance. They comprise two major subsets, cDC1 and cDC2, both derived from circulating precursors of cDCs (pre-cDCs), which exited the bone marrow. Authors show that, in the steady-state mouse, pre-cDCs entering tissues proliferate to give rise to differentiated cDCs, which themselves have residual proliferative capacity.

Striking imaging techniques and the use of multicolor fate-mapping reveal how conventional dendritic cells are seeded in the lungs and intestine. This work by Cabeza-Cabrerizo, van Blijswijk, et al also show how local infection influences the local dendritic cell population to replace and increase cells during inflammation.

Read more in: Science Immunology 01 Mar 2019: Vol. 4, Issue 33, DOI.

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