Enhanced IL-36R signaling promotes barrier impairment and inflammation in skin and intestine
Deficiency in interleukin-36R (IL-36R) antagonist caused by loss-of-function mutations in IL-36RN leads to DITRA (deficiency of IL-36 receptor antagonist), a rare inflammatory human disease that belongs to a subgroup of generalized pustular psoriasis (GPP).
- Immune & Epithelial Interactions
- Inflammatory Bowel
- Gastrointestinal System