Aberrant type 1 immunity drives susceptibility to mucosal fungal infections

In this month's issue of Science, Break et al. report that oral susceptibility of Aire-deficient mice to C. albicans is not due to aberrant type 17 responses. Rather, the overproduction of interferon-γ by local CD4+/CD8+ T cells that disrupt the epithelial barrier, increasing susceptibility to C. albicans invasion.